Search results for "reaction time variability"

showing 2 items of 2 documents

Genetic analysis of reaction time variability: room for improvement?

2013

Background. Increased reaction time variability (RTV) on cognitive tasks requiring a speeded response is characteristic of several psychiatric disorders. In attention deficit hyperactivity disorder (ADHD), the association with RT is strong phenotypically and genetically, yet high RTV is not a stable impairment but shows ADHD-sensitive improvement under certain conditions, such as those with rewards. The state regulation theory proposed that the RTV difference score, which captures change from baseline to a rewarded or fast condition, specifically measures ‘state regulation’. By contrast, the interpretation of RTV baseline (slow, unrewarded) scores is debated. We aimed to investigate directl…

Maleevent rateAdolescentDEFICIT HYPERACTIVITY DISORDERTWINS EARLY DEVELOPMENTMedizinTwinsSocial Sciences610 Medicine & health3202 Applied PsychologyBEHAVIOR PROBLEMS2738 Psychiatry and Mental HealthrewardsReaction TimeTwins Dizygoticddc:61ADHDHumansddc:610Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie Psychosomatik und Psychotherapie des Kindes- und JugendaltersChildModels GeneticATTENTION-DEFICIT/HYPERACTIVITY DISORDEROriginal ArticlesTwins Monozygotic10058 Department of Child and Adolescent PsychiatryPERFORMANCEInhibition PsychologicalPhenotypereaction time variabilityAttention Deficit Disorder with HyperactivityCONDUCT DISORDERCase-Control StudiesRELIABILITYINTRASUBJECT VARIABILITYFemalegenetic effectsCRITERION VALIDITYPsychological Medicine
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Polygenic association between attention-deficit/hyperactivity disorder liability and cognitive impairments.

2022

AbstractBackgroundA recent genome-wide association study (GWAS) identified 12 independent loci significantly associated with attention-deficit/hyperactivity disorder (ADHD). Polygenic risk scores (PRS), derived from the GWAS, can be used to assess genetic overlap between ADHD and other traits. Using ADHD samples from several international sites, we derived PRS for ADHD from the recent GWAS to test whether genetic variants that contribute to ADHD also influence two cognitive functions that show strong association with ADHD: attention regulation and response inhibition, captured by reaction time variability (RTV) and commission errors (CE).MethodsThe discovery GWAS included 19 099 ADHD cases …

cognitionTrastorns per dèficit d'atenció amb hiperactivitat en els infantsMedizinSocial SciencesGenome-wide association studyAttention deficit disorder with hyperactivity in children3202 Applied Psychology2738 Psychiatry and Mental Health0302 clinical medicineAtencióDUPLICATIONS2.1 Biological and endogenous factorsPsychologyAetiologyGenetic riskChildPOPULATIONApplied PsychologyResponse inhibitionPsychiatryREACTION-TIME VARIABILITYCognition10058 Department of Child and Adolescent PsychiatryinhibitionPsychiatry and Mental healthPhenotypeMental Healthpolygenic risk scoresreaction time variabilityCognicióPublic Health and Health Services/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingTrastorns per dèficit d'atenció amb hiperactivitat en els adultsRESPONSE-INHIBITIONClinical psychologyAdultAdolescentDEFICIT HYPERACTIVITY DISORDER610 Medicine & healthGENETIC RISKbehavioral disciplines and activitiesYoung Adult03 medical and health sciencesWORKING-MEMORYSDG 3 - Good Health and Well-beingmental disordersReaction TimeGeneticsmedicineHumansAttention deficit hyperactivity disorderADHDCognitive DysfunctionGENOME-WIDE ASSOCIATIONAssociation (psychology)business.industryPreventionHuman GenomeNeurosciencesGenetic variantsPERFORMANCEmedicine.diseaseAttention Deficit Hyperactivity Disorder (ADHD)030227 psychiatryattentionAttention Deficit Disorder with HyperactivityInhibicióCase-Control StudiesAttention deficit disorder with hyperactivity in adultsPolygenic risk scorebusiness030217 neurology & neurosurgeryGenome-Wide Association StudyPsychological medicine
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